Understanding the causes of the backwardness of the Muslim World has been the subject of research in the late three decades. Although much research has been done on this subject, cultural causes have been neglected. This is while culture seems to play an important role in the economic and political development of countries. The cultural crisis is one of the fundamental problems of the Islamic world that has been reflected in most of Imam Khomeini's speeches. The purpose of this study is to investigate Imam Khomeini's view on the cultural challenges of Islamic states using the theory of crisis of Thomas A. Spragens. The findings of this article refer to cultural problems such as westernization, division, self-destruction, emotional-spiritual dependence and crisis of meaning and identity, political and economic instability, the intervention of foreign powers, etc.