"Otherness" is one of the most important dimensions in understanding Islamic discourse in international relations. This arises from a critique of the ontology, epistemology, and methodology of the Western discourse of international relations. In fact, the formation of the Islamic discourse of international relations has two dimensions. On the one hand, the principles governing international relations with a focus on rationalist approaches are criticized, and on the other hand, its identity elements are presented based on the political discourse of Islam. This article tries to examine the process of otherness in the Islamic discourse of international relations by focusing on the Islamic Revolution of Iran approach in international politics.